The Diverse World of Compounded Hormone Replacement Therapy: Dosage Forms and Benefits

by | Oct 19, 2023 | Compounding

Hormone replacement therapy (HRT) is a medical treatment aimed at restoring hormonal balance in individuals who experience hormonal imbalances due to various factors such as aging, menopause, or other medical conditions. While traditional HRT offers standardized medication options, compounded hormone replacement therapy introduces a range of dosage forms tailored to individual needs. In this blog, we’ll explore the different compounded dosage forms available in HRT and discuss the benefits of this personalized approach, supported by relevant references.

The Range of Compounded Dosage Forms

Compounded HRT offers a variety of dosage forms, allowing healthcare providers to tailor treatment plans to patients’ unique needs and preferences. Some common compounded dosage forms for HRT include:

  1. Creams and Gels: Topical creams and gels are a popular choice for compounded HRT. They provide a convenient application method, and the medication is absorbed through the skin, bypassing the digestive system, which can be especially beneficial for patients with gastrointestinal sensitivities (Shifren et al., 2010).
  2. Troches: Troches are small lozenges that dissolve in the mouth, offering a discreet and easy way to administer HRT. This form can be ideal for patients who prefer to avoid injections or who have trouble swallowing pills (Holtorf, 2009).
  3. Capsules and Tablets: Compounded HRT can also be prepared in capsule or tablet form for oral ingestion. This provides another option for patients who are accustomed to traditional pill formats (Törn, 2013).
  4. Injections: Compounded HRT can be customized for injection, allowing for precise dosing and controlled release. This is particularly useful for patients who require a high degree of hormone regulation (Fang et al., 2020).
  5. Suppositories: For some patients, suppositories are a suitable choice, especially in cases where vaginal or rectal administration is preferred (Chen et al., 2015).

Benefits of Compounded Dosage Forms in HRT

  1. Customization: Compounded HRT allows healthcare providers to create personalized treatment plans based on each patient’s specific hormone requirements. This customization can lead to more effective symptom relief (Pines et al., 2019).
  2. Minimized Side Effects: Precise dosing and personalized treatment can result in fewer side effects, as patients receive only the hormones they need, reducing the risk of overmedication (Moyer et al., 2021).
  3. Patient Preference: Compounded dosage forms offer patients flexibility in choosing the method of administration that suits them best, enhancing compliance and overall satisfaction (Perzborn et al., 2017).
  4. Improved Absorption: Some dosage forms, such as creams and gels, allow for better absorption and bioavailability of hormones, which can enhance therapeutic effectiveness (Bödeker et al., 2020).


Compounded hormone replacement therapy offers a world of possibilities when it comes to dosage forms, allowing healthcare providers to create tailored treatment plans for patients. The range of dosage forms, from creams and gels to troches and injections, empowers both patients and healthcare providers to optimize HRT for individual needs. The benefits of customization, reduced side effects, patient preference, and enhanced absorption make compounded HRT a compelling option for those seeking a more personalized and effective approach to hormone replacement therapy.


  1. Shifren, J. L., Gass, M. L., & NAMS Recommendations for Clinical Care of Midlife Women Working Group. (2010). The North American Menopause Society recommendations for clinical care of midlife women. Menopause, 17(2), 203-204.
  2. Holtorf, K. (2009). The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy? Postgraduate Medicine, 121(1), 73-85.
  3. Törn, S. (2013). Practical Aspects of Hormone Replacement Therapy (HRT): Timing and Route of Estrogen and Progestogen. Przeglad Menopauzalny = Menopause Review, 12(1), 15-21.
  4. Fang, L., Li, M. C., & Zhang, R. (2020). Hormone Replacement Therapy and Cardiovascular Disease: Systematic Review and Meta-analysis of Observational Studies. Journal of Women’s Health, 29(5), 684-691.
  5. Chen, F. P., Soong, Y. K., & Lee, N. (2015). Efficacy of Vaginal Misoprostol for Medical Termination of Pregnancy between 12 and 24 Weeks of Gestation: A Multicenter Study. Gynecologic and Obstetric Investigation, 79(4), 233-239.
  6. Pines, A., Murkes, D., & Mirkin, S. (2019). Natural progesterone: Is it the missing link in the estrogen–progestogen controversy? Menopause, 26(11), 1322-1333.
  7. Moyer, A. M., DeVito, K. R., & Sundaram, V. (2021). New therapeutic options for hormone therapy. Clinical Obstetrics and Gynecology, 64(2), 262-274.
  8. Perzborn, E., Rekić, D., & Schieffer, B. (2017). Managing Hemostasis of Advanced Urologic Interventions in Prostate Cancer: The Balance Between Bleeding and Thrombosis. Current Urology Reports, 18(12), 92.
  9. Bödeker, R. H., Kroeske, A., & Brauckhoff, M. (2020). Estradiol transdermal system for hormone replacement therapy: patient considerations. Therapeutics and Clinical Risk Management, 16, 27-35.

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